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KMID : 0620920180500110147
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Experimental & Molecular Medicine
2018 Volume.50 No. 11 p.147 ~ p.147
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Clinical significance of APOB inactivation in hepatocellular carcinoma
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Lee Gena
Jeong Yun-Seong
Kim Do-Won
Kwak Min-Jun
Koh Ji-Won
Joo Eun-Wook
Lee Ju-Seog
Kah Susie
Sim Yeong-Eun
Yim Sun-Young
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Abstract
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Recent findings from The Cancer Genome Atlas project have provided a comprehensive map of genomic alterations that occur in hepatocellular carcinoma (HCC), including unexpected mutations in apolipoprotein B (APOB). We aimed to determine the clinical significance of this non-oncogenetic mutation in HCC. An Apob gene signature was derived from genes that differed between control mice and mice treated with siRNA specific for Apob (1.5-fold difference; P?
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KEYWORD
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Cancer genomics, Liver cancer, Prognostic markers
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